Medications That Cause Gynecomastia

There are several pharmacologic agents or medications that could cause gynecomastia. Although the risk of male breast enlargement secondary to certain medications are very low, one should be aware of which drugs can cause gynecomastia. The following drugs are associated with gynecomastia:

Marijuana (Cannabis sativa)
Androgens as found in anabolic steroids
Estrogen containing medications
Stilbestrol - medication used to treat prostate cancer
Anti-androgen medications
Chorionic gonadotropin
Diazepam
Digitalis
Ergotamine
Hydantoin
Hydroxyzine
Isoniazid
Lunesta
Methyldopa
Meprobamate
Pepcid
Tagamet
Reserpine
Spironolactone

I recommend consulting your primary care physician regarding these medications ifgynecomastia is a major concern for you. If your medical doctor decides to stop the medication, the breast enlargement may go away. One should not stop taking their medications without the consultation of your physician.

Emmanuel De La Cruz M.D. Reference: Ersek RA, Schaefenele M, Salisbury MA, et al. Gynecomastia: A clinical review. Aesth Surg J. 2000;20(5):381-6.